apart from the whole network stuff, you really should not run anything which isn’t reboot proof. I do run servers often for a long time without rebooting as well - however, only if I trust them to come back online with all service if a reboot for whatever reason happens or is needed - think of power failures and whatnot.
so do some maintenance and reboot that thing. and after you checked and updated everything properly reboot it again twice to make sure all services come back up as intended. then you can sleep better for the next two years even if @Ryan forgets to buy enough fuel for the generators